Herein, we report the application of a chemometric tool for the optimisation of\nelectrochemical biosensor performances. The experimental design was performed based on the\nresponses of an amperometric biosensor developed for metal ions detection using the flow injection\nanalysis. The electrode preparation and the working conditions were selected as experimental\nparameters, and thus, were modelled by a response surface methodology (RSM). In particular,\nenzyme concentration, flow rates, and number of cycles were reported as continuous factors, while\nthe sensitivities of the biosensor...
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